DECAPRYN vs VISTARIL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. DECAPRYN and VISTARIL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DECAPRYN	VISTARIL
Rating	70/100	64/100
Pharmacy pays	—	$0.04 /mL
Type	RX	RX
Active ingredient	DOXYLAMINE SUCCINATE	HYDROXYZINE HYDROCHLORIDE
Manufacturer	Sanofi Aventis US	Pfizer
Dosage forms	Tablet	Capsule, Injectable
Drug class	Antihistamine	Antihistamine
Boxed warning	None	None
Half-life	—	about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)
Treats	Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis	Anxiety Disorders, Nausea, Pruritus

decapryn vistaril

Rating

70/100

64/100

Pharmacy pays

—

$0.04 /mL

Type

Active ingredient

DOXYLAMINE SUCCINATE

HYDROXYZINE HYDROCHLORIDE

Manufacturer

Sanofi Aventis US

Pfizer

Dosage forms

Tablet

Capsule, Injectable

Drug class

Antihistamine

Boxed warning

None

Half-life

—

about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)

Treats

Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

Anxiety Disorders, Nausea, Pruritus

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Frequently asked questions

Which is better-rated, Decapryn or Vistaril?

By our independent rating, Decapryn scores higher — 3.5 vs 3.2 out of 5 for Vistaril. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Decapryn and Vistaril?

Decapryn contains Doxylamine Succinate, while Vistaril contains Hydroxyzine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.