DECAPRYN vs UNISOM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	DECAPRYN	UNISOM
Rating	70/100	64/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	DOXYLAMINE SUCCINATE	DOXYLAMINE SUCCINATE
Manufacturer	Sanofi Aventis US	Pfizer
Dosage forms	Tablet	Capsule, Tablet
Drug class	Antihistamine	Antihistamine
Boxed warning	None	None
Treats	Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis	Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

decapryn unisom

Rating

70/100

64/100

Pharmacy pays

—

Type

Active ingredient

DOXYLAMINE SUCCINATE

Manufacturer

Sanofi Aventis US

Pfizer

Dosage forms

Tablet

Capsule, Tablet

Drug class

Antihistamine

Boxed warning

None

Treats

Headache, Sleep Initiation and Maintenance Disorders, Perennial Allergic Rhinitis

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Frequently asked questions

Which is better-rated, Decapryn or Unisom?

By our independent rating, Decapryn scores higher — 3.5 vs 3.2 out of 5 for Unisom. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Decapryn and Unisom?

Both Decapryn and Unisom share the active ingredient Doxylamine Succinate.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.