DECADRON vs DEPO-MEDROL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 5, 2026·How we rate

Possible drug interaction. DECADRON and DEPO-MEDROL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DECADRON	DEPO-MEDROL
Rating	72/100	52/100
Pharmacy pays	$0.24 /mL	~$30.69 /30
Type	RX	RX
Active ingredient	DEXAMETHASONE	METHYLPREDNISOLONE ACETATE
Manufacturer	Merck	Pfizer
Dosage forms	Tablet	Injectable
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 4 hours	—
Treats	Addison Disease, Brain Edema, Bursitis	Adrenal Insufficiency, Asthma, Berylliosis

decadron depo-medrol

Rating

72/100

52/100

Pharmacy pays

$0.24 /mL

~$30.69 /30

Type

Active ingredient

DEXAMETHASONE

METHYLPREDNISOLONE ACETATE

Manufacturer

Merck

Pfizer

Dosage forms

Tablet

Injectable

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 4 hours

—

Treats

Addison Disease, Brain Edema, Bursitis

Adrenal Insufficiency, Asthma, Berylliosis

Frequently asked questions

Which is better-rated, Decadron or Depo-Medrol?

By our independent rating, Decadron scores higher — 3.6 vs 2.6 out of 5 for Depo-Medrol. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Decadron and Depo-Medrol?

Decadron contains Dexamethasone, while Depo-Medrol contains Methylprednisolone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.