DAYTRANA vs RELEXXII

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. DAYTRANA and RELEXXII are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DAYTRANA	RELEXXII
Rating	54/100	70/100
Pharmacy pays	~$18.94 /30	~$18.94 /30
Type	RX	RX
Active ingredient	METHYLPHENIDATE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Noven Pharms Inc	Osmotica Pharm US
Dosage forms	Patch	Tablet, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 2.7 hours	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

daytrana relexxii

Rating

54/100

70/100

Pharmacy pays

~$18.94 /30

Type

Active ingredient

METHYLPHENIDATE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Noven Pharms Inc

Osmotica Pharm US

Dosage forms

Patch

Tablet, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is better-rated, Daytrana or Relexxii?

By our independent rating, Relexxii scores higher — 3.5 vs 2.7 out of 5 for Daytrana. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Daytrana or Relexxii?

Pharmacies pay about the same to acquire either one — roughly $18.94 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Daytrana and Relexxii?

Daytrana contains Methylphenidate, while Relexxii contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.