DAYPRO vs DICLOFENAC SODIUM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. DAYPRO and DICLOFENAC SODIUM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DAYPRO	DICLOFENAC SODIUM
Rating	64/100	70/100
Pharmacy pays	~$17.64 /30	$0.36 /mL
Type	RX	RX
Active ingredient	OXAPROZIN	DICLOFENAC SODIUM
Manufacturer	Pfizer	Amneal
Dosage forms	Tablet	Solution, Drops, Topical, Tablet, delayed release, Tablet, extended release, Tablet, Kit
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	Boxed warning
Half-life	—	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Osteoarthritis	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

daypro diclofenac sodium

Rating

64/100

70/100

Pharmacy pays

~$17.64 /30

$0.36 /mL

Type

Active ingredient

OXAPROZIN

DICLOFENAC SODIUM

Manufacturer

Pfizer

Amneal

Dosage forms

Tablet

Solution, Drops, Topical, Tablet, delayed release, Tablet, extended release, Tablet, Kit

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Boxed warning

Half-life

—

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Osteoarthritis

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

Which is better-rated, Daypro or Diclofenac Sodium?

By our independent rating, Diclofenac Sodium scores higher — 3.5 vs 3.2 out of 5 for Daypro. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Daypro and Diclofenac Sodium?

Daypro contains Oxaprozin, while Diclofenac Sodium contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.