DAYPRO ALTA vs PENNSAID

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. DAYPRO ALTA and PENNSAID are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DAYPRO ALTA	PENNSAID
Rating	64/100	New
Pharmacy pays	~$17.64 /30	$0.36 /mL
Type	RX	RX
Active ingredient	OXAPROZIN POTASSIUM	DICLOFENAC SODIUM
Manufacturer	Pfizer	Horizon
Dosage forms	Tablet	Solution
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	—	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Osteoarthritis	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

daypro alta pennsaid

Rating

64/100

New

Pharmacy pays

~$17.64 /30

$0.36 /mL

Type

Active ingredient

OXAPROZIN POTASSIUM

DICLOFENAC SODIUM

Manufacturer

Pfizer

Horizon

Dosage forms

Tablet

Solution

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

—

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Osteoarthritis

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

What is the difference between Daypro Alta and Pennsaid?

Daypro Alta contains Oxaprozin Potassium, while Pennsaid contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.