CYMBALTA vs KHEDEZLA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. CYMBALTA and KHEDEZLA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CYMBALTA	KHEDEZLA
Rating	New	70/100
Pharmacy pays	~$3.41 /30	~$115.24 /30
Type	RX	RX
Active ingredient	DULOXETINE HYDROCHLORIDE	DESVENLAFAXINE
Manufacturer	Lilly	Osmotica Pharm US
Dosage forms	Capsule, delayed release	Tablet, extended release
Drug class	Serotonin and Norepinephrine Reuptake Inhibitor	Serotonin and Norepinephrine Reuptake Inhibitor
Boxed warning	None	None
Half-life	about 12 hours (typically 8 to 17 hours)	—
Treats	Anxiety Disorders, Major Depressive Disorder, Diabetic Neuropathies	Major Depressive Disorder

cymbalta khedezla

Rating

New

70/100

Pharmacy pays

~$3.41 /30

~$115.24 /30

Type

Active ingredient

DULOXETINE HYDROCHLORIDE

DESVENLAFAXINE

Manufacturer

Lilly

Osmotica Pharm US

Dosage forms

Capsule, delayed release

Tablet, extended release

Drug class

Serotonin and Norepinephrine Reuptake Inhibitor

Boxed warning

None

Half-life

about 12 hours (typically 8 to 17 hours)

—

Treats

Anxiety Disorders, Major Depressive Disorder, Diabetic Neuropathies

Major Depressive Disorder

Frequently asked questions

Which is cheaper, Cymbalta or Khedezla?

Cymbalta costs pharmacies less to acquire — about $3.41 vs $115.24 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Cymbalta and Khedezla?

Cymbalta contains Duloxetine Hydrochloride, while Khedezla contains Desvenlafaxine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.