CYMBALTA vs FETZIMA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. CYMBALTA and FETZIMA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CYMBALTA	FETZIMA
Rating	New	72/100
Pharmacy pays	~$3.41 /30	—
Type	RX	RX
Active ingredient	DULOXETINE HYDROCHLORIDE	LEVOMILNACIPRAN HYDROCHLORIDE
Manufacturer	Lilly	Abbvie
Dosage forms	Capsule, delayed release	Capsule, extended release, Kit
Drug class	Serotonin and Norepinephrine Reuptake Inhibitor	Serotonin and Norepinephrine Reuptake Inhibitor
Boxed warning	None	Boxed warning
Half-life	about 12 hours (typically 8 to 17 hours)	about 12 hours
Treats	Anxiety Disorders, Major Depressive Disorder, Diabetic Neuropathies	Major Depressive Disorder

cymbalta fetzima

Rating

New

72/100

Pharmacy pays

~$3.41 /30

—

Type

Active ingredient

DULOXETINE HYDROCHLORIDE

LEVOMILNACIPRAN HYDROCHLORIDE

Manufacturer

Lilly

Abbvie

Dosage forms

Capsule, delayed release

Capsule, extended release, Kit

Drug class

Serotonin and Norepinephrine Reuptake Inhibitor

Boxed warning

None

Boxed warning

Half-life

about 12 hours (typically 8 to 17 hours)

about 12 hours

Treats

Anxiety Disorders, Major Depressive Disorder, Diabetic Neuropathies

Major Depressive Disorder

Frequently asked questions

What is the difference between Cymbalta and Fetzima?

Cymbalta contains Duloxetine Hydrochloride, while Fetzima contains Levomilnacipran Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.