CYMBALTA vs DESVENLAFAXINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. CYMBALTA and DESVENLAFAXINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CYMBALTA	DESVENLAFAXINE
Rating	New	New
Pharmacy pays	~$3.41 /30	~$115.24 /30
Type	RX	RX
Active ingredient	DULOXETINE HYDROCHLORIDE	DESVENLAFAXINE
Manufacturer	Lilly	Anchen Pharms
Dosage forms	Capsule, delayed release	Tablet, extended release
Drug class	Serotonin and Norepinephrine Reuptake Inhibitor	Serotonin and Norepinephrine Reuptake Inhibitor
Boxed warning	None	None
Half-life	about 12 hours (typically 8 to 17 hours)	—
Treats	Anxiety Disorders, Major Depressive Disorder, Diabetic Neuropathies	Major Depressive Disorder

cymbalta desvenlafaxine

Rating

New

Pharmacy pays

~$3.41 /30

~$115.24 /30

Type

Active ingredient

DULOXETINE HYDROCHLORIDE

DESVENLAFAXINE

Manufacturer

Lilly

Anchen Pharms

Dosage forms

Capsule, delayed release

Tablet, extended release

Drug class

Serotonin and Norepinephrine Reuptake Inhibitor

Boxed warning

None

Half-life

about 12 hours (typically 8 to 17 hours)

—

Treats

Anxiety Disorders, Major Depressive Disorder, Diabetic Neuropathies

Major Depressive Disorder

Frequently asked questions

Which is cheaper, Cymbalta or Desvenlafaxine?

Cymbalta costs pharmacies less to acquire — about $3.41 vs $115.24 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Cymbalta and Desvenlafaxine?

Cymbalta contains Duloxetine Hydrochloride, while Desvenlafaxine contains Desvenlafaxine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.