CUVRIOR vs DEPEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. CUVRIOR and DEPEN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CUVRIOR	DEPEN
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	TRIENTINE TETRAHYDROCHLORIDE	PENICILLAMINE
Manufacturer	Orphalan	Mylan Speciality LP
Dosage forms	Tablet	Tablet
Drug class	—	Antirheumatic Agent
Boxed warning	None	Boxed warning
Treats	Hepatolenticular Degeneration, Nervous System Heavy Metal Poisoning	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

cuvrior depen

Rating

New

Pharmacy pays

—

Type

Active ingredient

TRIENTINE TETRAHYDROCHLORIDE

PENICILLAMINE

Manufacturer

Orphalan

Mylan Speciality LP

Dosage forms

Tablet

Drug class

—

Antirheumatic Agent

Boxed warning

None

Boxed warning

Treats

Hepatolenticular Degeneration, Nervous System Heavy Metal Poisoning

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

What is the difference between Cuvrior and Depen?

Cuvrior contains Trientine Tetrahydrochloride, while Depen contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.