CUPRIMINE vs SMOFLIPID 20%

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. CUPRIMINE and SMOFLIPID 20% are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CUPRIMINE	SMOFLIPID 20%
Rating	74/100	66/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	PENICILLAMINE	FISH OIL AND MEDIUM CHAIN TRIGLYCERIDES AND OLIVE OIL AND SOYBEAN OIL
Manufacturer	Valeant Pharm Intl	Fresenius Kabi USA
Dosage forms	Capsule	Injectable, Emulsion
Drug class	Antirheumatic Agent	—
Boxed warning	Boxed warning	None
Treats	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration	—

cuprimine smoflipid 20%

Rating

74/100

66/100

Pharmacy pays

—

Type

Active ingredient

PENICILLAMINE

FISH OIL AND MEDIUM CHAIN TRIGLYCERIDES AND OLIVE OIL AND SOYBEAN OIL

Manufacturer

Valeant Pharm Intl

Fresenius Kabi USA

Dosage forms

Capsule

Injectable, Emulsion

Drug class

Antirheumatic Agent

—

Boxed warning

None

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

—

Frequently asked questions

Which is better-rated, Cuprimine or Smoflipid 20%?

By our independent rating, Cuprimine scores higher — 3.7 vs 3.3 out of 5 for Smoflipid 20%. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cuprimine and Smoflipid 20%?

Cuprimine contains Penicillamine, while Smoflipid 20% contains Fish Oil and Medium Chain Triglycerides and Olive Oil and Soybean Oil — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.