CUPRIMINE vs PHENERGAN W/ CODEINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. CUPRIMINE and PHENERGAN W/ CODEINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CUPRIMINE	PHENERGAN W/ CODEINE
Rating	74/100	72/100
Pharmacy pays	—	~$20.54 /30
Type	RX	RX
Active ingredient	PENICILLAMINE	CODEINE PHOSPHATE AND PROMETHAZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE
Manufacturer	Valeant Pharm Intl	Ani Pharms
Dosage forms	Capsule	Syrup
Drug class	Antirheumatic Agent	—
Boxed warning	Boxed warning	None
Half-life	—	about 9 to 16 hours
Treats	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration	—

cuprimine phenergan w/ codeine

Rating

74/100

72/100

Pharmacy pays

—

~$20.54 /30

Type

Active ingredient

PENICILLAMINE

CODEINE PHOSPHATE AND PROMETHAZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE

Manufacturer

Valeant Pharm Intl

Ani Pharms

Dosage forms

Capsule

Syrup

Drug class

Antirheumatic Agent

—

Boxed warning

None

Half-life

—

about 9 to 16 hours

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

—

Frequently asked questions

Which is better-rated, Cuprimine or Phenergan W/ Codeine?

By our independent rating, Cuprimine scores higher — 3.7 vs 3.6 out of 5 for Phenergan W/ Codeine. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cuprimine and Phenergan W/ Codeine?

Cuprimine contains Penicillamine, while Phenergan W/ Codeine contains Codeine Phosphate and Promethazine Hydrochloride and Phenylephrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.