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CUPRIMINE vs PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. CUPRIMINE and PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

74/100
62/100

Pharmacy pays

—
~$2.80 /30

Type

RX
RX

Active ingredient

PENICILLAMINE
AMITRIPTYLINE HYDROCHLORIDE AND PERPHENAZINE

Dosage forms

Capsule
Tablet

Drug class

Antirheumatic Agent
—

Boxed warning

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration
—

Frequently asked questions

Which is better-rated, Cuprimine or Perphenazine and Amitriptyline Hydrochloride?

By our independent rating, Cuprimine scores higher — 3.7 vs 3.1 out of 5 for Perphenazine and Amitriptyline Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cuprimine and Perphenazine and Amitriptyline Hydrochloride?

Cuprimine contains Penicillamine, while Perphenazine and Amitriptyline Hydrochloride contains Amitriptyline Hydrochloride and Perphenazine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.