CUPRIMINE vs MACROBID

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. CUPRIMINE and MACROBID are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CUPRIMINE	MACROBID
Rating	74/100	New
Pharmacy pays	—	$2.14 /mL
Type	RX	RX
Active ingredient	PENICILLAMINE	NITROFURANTOIN AND NITROFURANTOIN, MACROCRYSTALLINE
Manufacturer	Valeant Pharm Intl	Almatica
Dosage forms	Capsule	Capsule
Drug class	Antirheumatic Agent	—
Boxed warning	Boxed warning	None
Half-life	—	about 20 minutes (roughly 0.3 hours) for the parent drug in adults with normal kidney function
Treats	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration	—

cuprimine macrobid

Rating

74/100

New

Pharmacy pays

—

$2.14 /mL

Type

Active ingredient

PENICILLAMINE

NITROFURANTOIN AND NITROFURANTOIN, MACROCRYSTALLINE

Manufacturer

Valeant Pharm Intl

Almatica

Dosage forms

Capsule

Drug class

Antirheumatic Agent

—

Boxed warning

None

Half-life

—

about 20 minutes (roughly 0.3 hours) for the parent drug in adults with normal kidney function

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

—

Frequently asked questions

What is the difference between Cuprimine and Macrobid?

Cuprimine contains Penicillamine, while Macrobid contains Nitrofurantoin and Nitrofurantoin, Macrocrystalline — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.