CUPRIMINE vs LOTREL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. CUPRIMINE and LOTREL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CUPRIMINE	LOTREL
Rating	74/100	68/100
Pharmacy pays	—	~$0.33 /30
Type	RX	RX
Active ingredient	PENICILLAMINE	AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE
Manufacturer	Valeant Pharm Intl	Sandoz
Dosage forms	Capsule	Capsule
Drug class	Antirheumatic Agent	—
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 30 to 50 hours
Treats	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration	—

cuprimine lotrel

Rating

74/100

68/100

Pharmacy pays

—

~$0.33 /30

Type

Active ingredient

PENICILLAMINE

AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE

Manufacturer

Valeant Pharm Intl

Sandoz

Dosage forms

Capsule

Drug class

Antirheumatic Agent

—

Boxed warning

Half-life

—

about 30 to 50 hours

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

—

Frequently asked questions

Which is better-rated, Cuprimine or Lotrel?

By our independent rating, Cuprimine scores higher — 3.7 vs 3.4 out of 5 for Lotrel. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cuprimine and Lotrel?

Cuprimine contains Penicillamine, while Lotrel contains Amlodipine Besylate and Benazepril Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.