CUPRIMINE vs JANUMET XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. CUPRIMINE and JANUMET XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CUPRIMINE	JANUMET XR
Rating	74/100	New
Pharmacy pays	—	~$0.74 /30
Type	RX	RX
Active ingredient	PENICILLAMINE	METFORMIN HYDROCHLORIDE AND SITAGLIPTIN PHOSPHATE
Manufacturer	Valeant Pharm Intl	Msd Sub Merck
Dosage forms	Capsule	Tablet, extended release
Drug class	Antirheumatic Agent	—
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 12.4 hours (apparent terminal half-life after a single 100 mg oral dose in healthy volunteers)
Treats	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration	—

cuprimine janumet xr

Rating

74/100

New

Pharmacy pays

—

~$0.74 /30

Type

Active ingredient

PENICILLAMINE

METFORMIN HYDROCHLORIDE AND SITAGLIPTIN PHOSPHATE

Manufacturer

Valeant Pharm Intl

Msd Sub Merck

Dosage forms

Capsule

Tablet, extended release

Drug class

Antirheumatic Agent

—

Boxed warning

Half-life

—

about 12.4 hours (apparent terminal half-life after a single 100 mg oral dose in healthy volunteers)

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

—

Frequently asked questions

What is the difference between Cuprimine and Janumet XR?

Cuprimine contains Penicillamine, while Janumet XR contains Metformin Hydrochloride and Sitagliptin Phosphate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.