CUPRIMINE vs FIORINAL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. CUPRIMINE and FIORINAL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CUPRIMINE	FIORINAL
Rating	74/100	72/100
Pharmacy pays	—	~$0.78 /30
Type	RX	RX
Active ingredient	PENICILLAMINE	ASPIRIN AND BUTALBITAL AND CAFFEINE
Manufacturer	Valeant Pharm Intl	Allergan
Dosage forms	Capsule	Tablet, Capsule
Drug class	Antirheumatic Agent	—
Boxed warning	Boxed warning	None
Half-life	—	about 20 minutes (the label also states 0.33 hours) for aspirin itself
Treats	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration	—

cuprimine fiorinal

Rating

74/100

72/100

Pharmacy pays

—

~$0.78 /30

Type

Active ingredient

PENICILLAMINE

ASPIRIN AND BUTALBITAL AND CAFFEINE

Manufacturer

Valeant Pharm Intl

Allergan

Dosage forms

Capsule

Tablet, Capsule

Drug class

Antirheumatic Agent

—

Boxed warning

None

Half-life

—

about 20 minutes (the label also states 0.33 hours) for aspirin itself

Treats

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

—

Frequently asked questions

Which is better-rated, Cuprimine or Fiorinal?

By our independent rating, Cuprimine scores higher — 3.7 vs 3.6 out of 5 for Fiorinal. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cuprimine and Fiorinal?

Cuprimine contains Penicillamine, while Fiorinal contains Aspirin and Butalbital and Caffeine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.