CRESTOR vs REPATHA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. CRESTOR and REPATHA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CRESTOR	REPATHA
Rating	70/100	72/100
Pharmacy pays	~$1.37 /30	—
Type	RX	RX
Active ingredient	ROSUVASTATIN CALCIUM	EVOLOCUMAB
Manufacturer	Astrazeneca	Amgen Inc
Dosage forms	Tablet	Injectable
Drug class	Hmg-Coa Reductase Inhibitor	—
Boxed warning	None	None
Half-life	about 19 hours	—
Treats	Coronary Artery Disease, Hypercholesterolemia, Hyperlipoproteinemias	Hypercholesterolemia, Atherosclerosis

crestor repatha

Rating

70/100

72/100

Pharmacy pays

~$1.37 /30

—

Type

Active ingredient

ROSUVASTATIN CALCIUM

EVOLOCUMAB

Manufacturer

Astrazeneca

Amgen Inc

Dosage forms

Tablet

Injectable

Drug class

Hmg-Coa Reductase Inhibitor

—

Boxed warning

None

Half-life

about 19 hours

—

Treats

Coronary Artery Disease, Hypercholesterolemia, Hyperlipoproteinemias

Hypercholesterolemia, Atherosclerosis

Frequently asked questions

Which is better-rated, Crestor or Repatha?

By our independent rating, Repatha scores higher — 3.6 vs 3.5 out of 5 for Crestor. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Crestor and Repatha?

Crestor contains Rosuvastatin Calcium, while Repatha contains Evolocumab — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.