COUMADIN vs PROPAFENONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. COUMADIN and PROPAFENONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COUMADIN	PROPAFENONE HYDROCHLORIDE
Rating	72/100	72/100
Pharmacy pays	~$2.58 /30	~$10.51 /30
Type	RX	RX
Active ingredient	WARFARIN SODIUM	PROPAFENONE HYDROCHLORIDE
Manufacturer	Bristol Myers Squibb	Rising
Dosage forms	Tablet	Capsule, extended release, Tablet
Drug class	Vitamin K Antagonist	Antiarrhythmic
Boxed warning	None	Boxed warning
Half-life	about 40 hours (the label's effective half-life; range 20 to 60 hours)	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers
Treats	Atrial Fibrillation, Postoperative Complications, Pulmonary Embolism	Atrial Fibrillation, Supraventricular Tachycardia

coumadin propafenone hydrochloride

Rating

72/100

Pharmacy pays

~$2.58 /30

~$10.51 /30

Type

Active ingredient

WARFARIN SODIUM

PROPAFENONE HYDROCHLORIDE

Manufacturer

Bristol Myers Squibb

Rising

Dosage forms

Tablet

Capsule, extended release, Tablet

Drug class

Vitamin K Antagonist

Antiarrhythmic

Boxed warning

None

Boxed warning

Half-life

about 40 hours (the label's effective half-life; range 20 to 60 hours)

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

Treats

Atrial Fibrillation, Postoperative Complications, Pulmonary Embolism

Atrial Fibrillation, Supraventricular Tachycardia

Frequently asked questions

Which is better-rated, Coumadin or Propafenone Hydrochloride?

Coumadin and Propafenone Hydrochloride are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Coumadin or Propafenone Hydrochloride?

Coumadin costs pharmacies less to acquire — about $2.58 vs $10.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Coumadin and Propafenone Hydrochloride?

Coumadin contains Warfarin Sodium, while Propafenone Hydrochloride contains Propafenone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.