COTEMPLA XR-ODT vs VYVANSE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. COTEMPLA XR-ODT and VYVANSE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COTEMPLA XR-ODT	VYVANSE
Rating	New	New
Pharmacy pays	~$18.94 /30	—
Type	RX	RX
Active ingredient	METHYLPHENIDATE	LISDEXAMFETAMINE DIMESYLATE
Manufacturer	Neos Theraps Inc	Takeda Pharms USA
Dosage forms	Tablet, orally disintegrating	Capsule, Tablet, chewable
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	about 2.7 hours	less than 1 hour (parent drug)
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Binge Drinking

cotempla xr-odt vyvanse

Rating

New

Pharmacy pays

~$18.94 /30

—

Type

Active ingredient

METHYLPHENIDATE

LISDEXAMFETAMINE DIMESYLATE

Manufacturer

Neos Theraps Inc

Takeda Pharms USA

Dosage forms

Tablet, orally disintegrating

Capsule, Tablet, chewable

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

about 2.7 hours

less than 1 hour (parent drug)

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Binge Drinking

Frequently asked questions

What is the difference between Cotempla XR-ODT and Vyvanse?

Cotempla XR-ODT contains Methylphenidate, while Vyvanse contains Lisdexamfetamine Dimesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.