COTEMPLA XR-ODT vs EVEKEO ODT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. COTEMPLA XR-ODT and EVEKEO ODT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COTEMPLA XR-ODT	EVEKEO ODT
Rating	New	70/100
Pharmacy pays	~$18.94 /30	~$478.55 /30
Type	RX	RX
Active ingredient	METHYLPHENIDATE	AMPHETAMINE SULFATE
Manufacturer	Neos Theraps Inc	Azurity
Dosage forms	Tablet, orally disintegrating	Tablet, orally disintegrating
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	None
Half-life	about 2.7 hours	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy	Attention Deficit Disorder with Hyperactivity, Narcolepsy

cotempla xr-odt evekeo odt

Rating

New

70/100

Pharmacy pays

~$18.94 /30

~$478.55 /30

Type

Active ingredient

METHYLPHENIDATE

AMPHETAMINE SULFATE

Manufacturer

Neos Theraps Inc

Azurity

Dosage forms

Tablet, orally disintegrating

Drug class

Central Nervous System Stimulant

Boxed warning

None

Half-life

about 2.7 hours

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Frequently asked questions

Which is cheaper, Cotempla XR-ODT or Evekeo ODT?

Cotempla XR-ODT costs pharmacies less to acquire — about $18.94 vs $478.55 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Cotempla XR-ODT and Evekeo ODT?

Cotempla XR-ODT contains Methylphenidate, while Evekeo ODT contains Amphetamine Sulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.