COTELLIC vs ZELBORAF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. COTELLIC and ZELBORAF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COTELLIC	ZELBORAF
Rating	70/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	COBIMETINIB FUMARATE	VEMURAFENIB
Manufacturer	Genentech Inc	Hoffmann La Roche
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	—
Boxed warning	None	None
Treats	Melanoma	Melanoma

cotellic zelboraf

Rating

70/100

New

Pharmacy pays

—

Type

Active ingredient

COBIMETINIB FUMARATE

VEMURAFENIB

Manufacturer

Genentech Inc

Hoffmann La Roche

Dosage forms

Tablet

Drug class

Kinase Inhibitor

—

Boxed warning

None

Treats

Melanoma

Frequently asked questions

What is the difference between Cotellic and Zelboraf?

Cotellic contains Cobimetinib Fumarate, while Zelboraf contains Vemurafenib — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.