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COTELLIC vs TEPMETKO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. COTELLIC and TEPMETKO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

cotellictepmetko

Rating

70/100
70/100

Pharmacy pays

—
—

Type

RX
RX

Active ingredient

COBIMETINIB FUMARATE
TEPOTINIB HYDROCHLORIDE

Manufacturer

Genentech Inc
Emd Serono

Dosage forms

Tablet
Tablet

Drug class

Kinase Inhibitor
Kinase Inhibitor

Boxed warning

None
None

Treats

Melanoma
—

Frequently asked questions

Which is better-rated, Cotellic or Tepmetko?

Cotellic and Tepmetko are tied at 3.5 out of 5 by our independent rating.

What is the difference between Cotellic and Tepmetko?

Cotellic contains Cobimetinib Fumarate, while Tepmetko contains Tepotinib Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.