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COTELLIC vs RETEVMO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. COTELLIC and RETEVMO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

Type

RX
RX

Active ingredient

COBIMETINIB FUMARATE
SELPERCATINIB

Dosage forms

Tablet
Capsule, Tablet

Drug class

Kinase Inhibitor
Kinase Inhibitor

Boxed warning

None
None

Treats

Melanoma
Non-Small-Cell Lung Carcinoma, Thyroid Neoplasms

Frequently asked questions

What is the difference between Cotellic and Retevmo?

Cotellic contains Cobimetinib Fumarate, while Retevmo contains Selpercatinib — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.