COTELLIC vs NERLYNX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. COTELLIC and NERLYNX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COTELLIC	NERLYNX
Rating	70/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	COBIMETINIB FUMARATE	NERATINIB MALEATE
Manufacturer	Genentech Inc	Puma Biotech
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Treats	Melanoma	Breast Neoplasms

cotellic nerlynx

Rating

70/100

New

Pharmacy pays

—

Type

Active ingredient

COBIMETINIB FUMARATE

NERATINIB MALEATE

Manufacturer

Genentech Inc

Puma Biotech

Dosage forms

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Treats

Melanoma

Breast Neoplasms

Frequently asked questions

What is the difference between Cotellic and Nerlynx?

Cotellic contains Cobimetinib Fumarate, while Nerlynx contains Neratinib Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.