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COTELLIC vs LORBRENA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. COTELLIC and LORBRENA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

cotelliclorbrena

Rating

70/100
64/100

Pharmacy pays

—
—

Type

RX
RX

Active ingredient

COBIMETINIB FUMARATE
LORLATINIB

Manufacturer

Genentech Inc
Pfizer

Dosage forms

Tablet
Tablet

Drug class

Kinase Inhibitor
Kinase Inhibitor

Boxed warning

None
None

Treats

Melanoma
—

Frequently asked questions

Which is better-rated, Cotellic or Lorbrena?

By our independent rating, Cotellic scores higher — 3.5 vs 3.2 out of 5 for Lorbrena. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cotellic and Lorbrena?

Cotellic contains Cobimetinib Fumarate, while Lorbrena contains Lorlatinib — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.