COTELLIC vs ICLUSIG

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. COTELLIC and ICLUSIG are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COTELLIC	ICLUSIG
Rating	70/100	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	COBIMETINIB FUMARATE	PONATINIB HYDROCHLORIDE
Manufacturer	Genentech Inc	Takeda Pharms USA
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	Boxed warning
Treats	Melanoma	Myeloid Leukemia

cotellic iclusig

Rating

70/100

New

Pharmacy pays

—

Type

Active ingredient

COBIMETINIB FUMARATE

PONATINIB HYDROCHLORIDE

Manufacturer

Genentech Inc

Takeda Pharms USA

Dosage forms

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Boxed warning

Treats

Melanoma

Myeloid Leukemia

Frequently asked questions

What is the difference between Cotellic and Iclusig?

Cotellic contains Cobimetinib Fumarate, while Iclusig contains Ponatinib Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.