COTELLIC vs GLEEVEC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. COTELLIC and GLEEVEC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COTELLIC	GLEEVEC
Rating	70/100	70/100
Pharmacy pays	—	~$25.80 /30
Type	RX	RX
Active ingredient	COBIMETINIB FUMARATE	IMATINIB MESYLATE
Manufacturer	Genentech Inc	Novartis
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Treats	Melanoma	Lymphoid Leukemia, Myeloid Leukemia, Hypereosinophilic Syndrome

cotellic gleevec

Rating

70/100

Pharmacy pays

—

~$25.80 /30

Type

Active ingredient

COBIMETINIB FUMARATE

IMATINIB MESYLATE

Manufacturer

Genentech Inc

Novartis

Dosage forms

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Treats

Melanoma

Lymphoid Leukemia, Myeloid Leukemia, Hypereosinophilic Syndrome

Frequently asked questions

Which is better-rated, Cotellic or Gleevec?

Cotellic and Gleevec are tied at 3.5 out of 5 by our independent rating.

What is the difference between Cotellic and Gleevec?

Cotellic contains Cobimetinib Fumarate, while Gleevec contains Imatinib Mesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.