COSMEGEN vs XATMEP

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. COSMEGEN and XATMEP are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COSMEGEN	XATMEP
Rating	New	72/100
Pharmacy pays	—	~$4.90 /30
Type	RX	RX
Active ingredient	DACTINOMYCIN	METHOTREXATE SODIUM
Manufacturer	Recordati Rare	Azurity
Dosage forms	Injectable	Solution
Drug class	Actinomycin	Folate Analog Metabolic Inhibitor
Boxed warning	None	Boxed warning
Half-life	—	about 3 to 10 hours
Treats	Choriocarcinoma, Melanoma, Wilms Tumor	Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

cosmegen xatmep

Rating

New

72/100

Pharmacy pays

—

~$4.90 /30

Type

Active ingredient

DACTINOMYCIN

METHOTREXATE SODIUM

Manufacturer

Recordati Rare

Azurity

Dosage forms

Injectable

Solution

Drug class

Actinomycin

Folate Analog Metabolic Inhibitor

Boxed warning

None

Boxed warning

Half-life

—

about 3 to 10 hours

Treats

Choriocarcinoma, Melanoma, Wilms Tumor

Juvenile Arthritis, Rheumatoid Arthritis, Breast Neoplasms

Frequently asked questions

What is the difference between Cosmegen and Xatmep?

Cosmegen contains Dactinomycin, while Xatmep contains Methotrexate Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.