COSMEGEN vs COTELLIC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. COSMEGEN and COTELLIC are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COSMEGEN	COTELLIC
Rating	New	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	DACTINOMYCIN	COBIMETINIB FUMARATE
Manufacturer	Recordati Rare	Genentech Inc
Dosage forms	Injectable	Tablet
Drug class	Actinomycin	Kinase Inhibitor
Boxed warning	None	None
Treats	Choriocarcinoma, Melanoma, Wilms Tumor	Melanoma

cosmegen cotellic

Rating

New

70/100

Pharmacy pays

—

Type

Active ingredient

DACTINOMYCIN

COBIMETINIB FUMARATE

Manufacturer

Recordati Rare

Genentech Inc

Dosage forms

Injectable

Tablet

Drug class

Actinomycin

Kinase Inhibitor

Boxed warning

None

Treats

Choriocarcinoma, Melanoma, Wilms Tumor

Melanoma

Frequently asked questions

What is the difference between Cosmegen and Cotellic?

Cosmegen contains Dactinomycin, while Cotellic contains Cobimetinib Fumarate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.