CORTRIL vs FLONASE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. CORTRIL and FLONASE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTRIL	FLONASE
Rating	64/100	72/100
Pharmacy pays	$0.15 /g	—
Type	RX	RX
Active ingredient	HYDROCORTISONE ACETATE	FLUTICASONE PROPIONATE
Manufacturer	Pfizer	Haleon US Holdings
Dosage forms	Tablet, Topical	Spray/Inhaler, metered
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	—
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Perennial Allergic Rhinitis

cortril flonase

Rating

64/100

72/100

Pharmacy pays

$0.15 /g

—

Type

Active ingredient

HYDROCORTISONE ACETATE

FLUTICASONE PROPIONATE

Manufacturer

Pfizer

Haleon US Holdings

Dosage forms

Tablet, Topical

Spray/Inhaler, metered

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Perennial Allergic Rhinitis

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Frequently asked questions

Which is better-rated, Cortril or Flonase?

By our independent rating, Flonase scores higher — 3.6 vs 3.2 out of 5 for Cortril. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cortril and Flonase?

Cortril contains Hydrocortisone Acetate, while Flonase contains Fluticasone Propionate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.