CORTRIL vs DIPROLENE AF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. CORTRIL and DIPROLENE AF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTRIL	DIPROLENE AF
Rating	60/100	72/100
Pharmacy pays	$0.14 /g	—
Type	RX	RX
Active ingredient	HYDROCORTISONE ACETATE	BETAMETHASONE DIPROPIONATE
Manufacturer	Pfizer	Organon
Dosage forms	Tablet, Topical	Topical, Augmented
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	—
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Atopic Dermatitis, Facial Dermatoses, Foot Dermatoses

cortril diprolene af

Rating

60/100

72/100

Pharmacy pays

$0.14 /g

—

Type

Active ingredient

HYDROCORTISONE ACETATE

BETAMETHASONE DIPROPIONATE

Manufacturer

Pfizer

Organon

Dosage forms

Tablet, Topical

Topical, Augmented

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Atopic Dermatitis, Facial Dermatoses, Foot Dermatoses

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Frequently asked questions

Which is better-rated, Cortril or Diprolene Af?

By our independent rating, Diprolene Af scores higher — 3.6 vs 3.0 out of 5 for Cortril. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cortril and Diprolene Af?

Cortril contains Hydrocortisone Acetate, while Diprolene Af contains Betamethasone Dipropionate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.