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CORTRIL vs DESONIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. CORTRIL and DESONIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

60/100
72/100

Pharmacy pays

$0.14 /g
$0.28 /g

Type

RX
RX

Active ingredient

HYDROCORTISONE ACETATE
DESONIDE

Dosage forms

Tablet, Topical
Topical

Drug class

Corticosteroid
Corticosteroid

Boxed warning

None
None

Half-life

about 1.5 hours
—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis
Facial Dermatoses, Foot Dermatoses, Hand Dermatoses

Get desonidehigher-rated option

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Frequently asked questions

Which is better-rated, Cortril or Desonide?

By our independent rating, Desonide scores higher — 3.6 vs 3.0 out of 5 for Cortril. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Cortril or Desonide?

Cortril costs pharmacies less to acquire — about $0.14 vs $0.28 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Cortril and Desonide?

Cortril contains Hydrocortisone Acetate, while Desonide contains Desonide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.