CORTONE vs SOLU-CORTEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. CORTONE and SOLU-CORTEF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTONE	SOLU-CORTEF
Rating	70/100	New
Pharmacy pays	—	$0.15 /g
Type	RX	RX
Active ingredient	CORTISONE ACETATE	HYDROCORTISONE SODIUM SUCCINATE
Manufacturer	Merck	Pharmacia and Upjohn
Dosage forms	Injectable, Tablet	Injectable
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	—	about 1.5 hours
Treats	Adrenal Insufficiency, Asthma, Berylliosis	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

cortone solu-cortef

Rating

70/100

New

Pharmacy pays

—

$0.15 /g

Type

Active ingredient

CORTISONE ACETATE

HYDROCORTISONE SODIUM SUCCINATE

Manufacturer

Merck

Pharmacia and Upjohn

Dosage forms

Injectable, Tablet

Injectable

Drug class

Corticosteroid

Boxed warning

None

Half-life

—

about 1.5 hours

Treats

Adrenal Insufficiency, Asthma, Berylliosis

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Frequently asked questions

What is the difference between Cortone and Solu-Cortef?

Cortone contains Cortisone Acetate, while Solu-Cortef contains Hydrocortisone Sodium Succinate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.