CORTENEMA vs ZILRETTA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. CORTENEMA and ZILRETTA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTENEMA	ZILRETTA
Rating	70/100	70/100
Pharmacy pays	$0.15 /g	—
Type	RX	RX
Active ingredient	HYDROCORTISONE	TRIAMCINOLONE ACETONIDE
Manufacturer	Ani Pharms	Pacira Pharms Inc
Dosage forms	Enema	Kit
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	—
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Adrenal Insufficiency, Hemolytic Anemia, Berylliosis

cortenema zilretta

Rating

70/100

Pharmacy pays

$0.15 /g

—

Type

Active ingredient

HYDROCORTISONE

TRIAMCINOLONE ACETONIDE

Manufacturer

Ani Pharms

Pacira Pharms Inc

Dosage forms

Enema

Kit

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Adrenal Insufficiency, Hemolytic Anemia, Berylliosis

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Frequently asked questions

Which is better-rated, Cortenema or Zilretta?

Cortenema and Zilretta are tied at 3.5 out of 5 by our independent rating.

What is the difference between Cortenema and Zilretta?

Cortenema contains Hydrocortisone, while Zilretta contains Triamcinolone Acetonide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.