CORTENEMA vs SERNIVO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate

Possible drug interaction. CORTENEMA and SERNIVO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTENEMA	SERNIVO
Rating	72/100	72/100
Pharmacy pays	$0.14 /g	—
Type	RX	RX
Active ingredient	HYDROCORTISONE	BETAMETHASONE DIPROPIONATE
Manufacturer	Ani Pharms	Primus Pharms
Dosage forms	Enema	Spray/Inhaler
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	—
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Atopic Dermatitis, Facial Dermatoses, Foot Dermatoses

cortenema sernivo

Rating

72/100

Pharmacy pays

$0.14 /g

—

Type

Active ingredient

HYDROCORTISONE

BETAMETHASONE DIPROPIONATE

Manufacturer

Ani Pharms

Primus Pharms

Dosage forms

Enema

Spray/Inhaler

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Atopic Dermatitis, Facial Dermatoses, Foot Dermatoses

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Frequently asked questions

Which is better-rated, Cortenema or Sernivo?

Cortenema and Sernivo are tied at 3.6 out of 5 by our independent rating.

What is the difference between Cortenema and Sernivo?

Cortenema contains Hydrocortisone, while Sernivo contains Betamethasone Dipropionate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.