CORTENEMA vs HYDROCORTONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. CORTENEMA and HYDROCORTONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTENEMA	HYDROCORTONE
Rating	70/100	70/100
Pharmacy pays	$0.15 /g	$0.15 /g
Type	RX	RX
Active ingredient	HYDROCORTISONE	HYDROCORTISONE ACETATE
Manufacturer	Ani Pharms	Merck
Dosage forms	Enema	Injectable, Tablet
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	about 1.5 hours
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

cortenema hydrocortone

Rating

70/100

Pharmacy pays

$0.15 /g

Type

Active ingredient

HYDROCORTISONE

HYDROCORTISONE ACETATE

Manufacturer

Ani Pharms

Merck

Dosage forms

Enema

Injectable, Tablet

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

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Frequently asked questions

Which is better-rated, Cortenema or Hydrocortone?

Cortenema and Hydrocortone are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Cortenema or Hydrocortone?

Pharmacies pay about the same to acquire either one — roughly $0.15 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Cortenema and Hydrocortone?

Cortenema contains Hydrocortisone, while Hydrocortone contains Hydrocortisone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.