CORTENEMA vs FLORONE E

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CORTENEMA and FLORONE E are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTENEMA	FLORONE E
Rating	70/100	64/100
Pharmacy pays	$0.15 /g	—
Type	RX	RX
Active ingredient	HYDROCORTISONE	DIFLORASONE DIACETATE
Manufacturer	Ani Pharms	Pfizer
Dosage forms	Enema	Topical
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	—
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Facial Dermatoses, Foot Dermatoses, Hand Dermatoses

cortenema florone e

Rating

70/100

64/100

Pharmacy pays

$0.15 /g

—

Type

Active ingredient

HYDROCORTISONE

DIFLORASONE DIACETATE

Manufacturer

Ani Pharms

Pfizer

Dosage forms

Enema

Topical

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Facial Dermatoses, Foot Dermatoses, Hand Dermatoses

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Frequently asked questions

Which is better-rated, Cortenema or Florone E?

By our independent rating, Cortenema scores higher — 3.5 vs 3.2 out of 5 for Florone E. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cortenema and Florone E?

Cortenema contains Hydrocortisone, while Florone E contains Diflorasone Diacetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.