CORTENEMA vs FLONASE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. CORTENEMA and FLONASE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTENEMA	FLONASE
Rating	70/100	72/100
Pharmacy pays	$0.15 /g	—
Type	RX	RX
Active ingredient	HYDROCORTISONE	FLUTICASONE PROPIONATE
Manufacturer	Ani Pharms	Haleon US Holdings
Dosage forms	Enema	Spray/Inhaler, metered
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	—
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Perennial Allergic Rhinitis

cortenema flonase

Rating

70/100

72/100

Pharmacy pays

$0.15 /g

—

Type

Active ingredient

HYDROCORTISONE

FLUTICASONE PROPIONATE

Manufacturer

Ani Pharms

Haleon US Holdings

Dosage forms

Enema

Spray/Inhaler, metered

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Perennial Allergic Rhinitis

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Frequently asked questions

Which is better-rated, Cortenema or Flonase?

By our independent rating, Flonase scores higher — 3.6 vs 3.5 out of 5 for Cortenema. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Cortenema and Flonase?

Cortenema contains Hydrocortisone, while Flonase contains Fluticasone Propionate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.