CORTENEMA vs DEXTENZA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. CORTENEMA and DEXTENZA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTENEMA	DEXTENZA
Rating	70/100	New
Pharmacy pays	$0.15 /g	$0.24 /mL
Type	RX	RX
Active ingredient	HYDROCORTISONE	DEXAMETHASONE
Manufacturer	Ani Pharms	Ocular Therapeutix
Dosage forms	Enema	Insert
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	about 4 hours
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Addison Disease, Brain Edema, Bursitis

cortenema dextenza

Rating

70/100

New

Pharmacy pays

$0.15 /g

$0.24 /mL

Type

Active ingredient

HYDROCORTISONE

DEXAMETHASONE

Manufacturer

Ani Pharms

Ocular Therapeutix

Dosage forms

Enema

Insert

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

about 4 hours

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Addison Disease, Brain Edema, Bursitis

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Frequently asked questions

What is the difference between Cortenema and Dextenza?

Cortenema contains Hydrocortisone, while Dextenza contains Dexamethasone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.