CORTENEMA vs CORTRIL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CORTENEMA and CORTRIL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTENEMA	CORTRIL
Rating	70/100	64/100
Pharmacy pays	$0.15 /g	$0.15 /g
Type	RX	RX
Active ingredient	HYDROCORTISONE	HYDROCORTISONE ACETATE
Manufacturer	Ani Pharms	Pfizer
Dosage forms	Enema	Tablet, Topical
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	about 1.5 hours
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

cortenema cortril

Rating

70/100

64/100

Pharmacy pays

$0.15 /g

Type

Active ingredient

HYDROCORTISONE

HYDROCORTISONE ACETATE

Manufacturer

Ani Pharms

Pfizer

Dosage forms

Enema

Tablet, Topical

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

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Frequently asked questions

Which is better-rated, Cortenema or Cortril?

By our independent rating, Cortenema scores higher — 3.5 vs 3.2 out of 5 for Cortril. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Cortenema or Cortril?

Pharmacies pay about the same to acquire either one — roughly $0.15 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Cortenema and Cortril?

Cortenema contains Hydrocortisone, while Cortril contains Hydrocortisone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.