CORTEF ACETATE vs CORTONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CORTEF ACETATE and CORTONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTEF ACETATE	CORTONE
Rating	New	70/100
Pharmacy pays	$0.15 /g	—
Type	RX	RX
Active ingredient	HYDROCORTISONE ACETATE	CORTISONE ACETATE
Manufacturer	Pharmacia and Upjohn	Merck
Dosage forms	Topical, Injectable	Injectable, Tablet
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	—
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Adrenal Insufficiency, Asthma, Berylliosis

cortef acetate cortone

Rating

New

70/100

Pharmacy pays

$0.15 /g

—

Type

Active ingredient

HYDROCORTISONE ACETATE

CORTISONE ACETATE

Manufacturer

Pharmacia and Upjohn

Merck

Dosage forms

Topical, Injectable

Injectable, Tablet

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Adrenal Insufficiency, Asthma, Berylliosis

Frequently asked questions

What is the difference between Cortef Acetate and Cortone?

Cortef Acetate contains Hydrocortisone Acetate, while Cortone contains Cortisone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.