CORTEF ACETATE vs CORTENEMA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CORTEF ACETATE and CORTENEMA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORTEF ACETATE	CORTENEMA
Rating	New	70/100
Pharmacy pays	$0.15 /g	$0.15 /g
Type	RX	RX
Active ingredient	HYDROCORTISONE ACETATE	HYDROCORTISONE
Manufacturer	Pharmacia and Upjohn	Ani Pharms
Dosage forms	Topical, Injectable	Enema
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	about 1.5 hours
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

cortef acetate cortenema

Rating

New

70/100

Pharmacy pays

$0.15 /g

Type

Active ingredient

HYDROCORTISONE ACETATE

HYDROCORTISONE

Manufacturer

Pharmacia and Upjohn

Ani Pharms

Dosage forms

Topical, Injectable

Enema

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

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Frequently asked questions

Which is cheaper, Cortef Acetate or Cortenema?

Pharmacies pay about the same to acquire either one — roughly $0.15 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Cortef Acetate and Cortenema?

Cortef Acetate contains Hydrocortisone Acetate, while Cortenema contains Hydrocortisone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.