CORT-DOME vs CORTONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. CORT-DOME and CORTONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CORT-DOME	CORTONE
Rating	New	70/100
Pharmacy pays	$0.15 /g	—
Type	RX	RX
Active ingredient	HYDROCORTISONE	CORTISONE ACETATE
Manufacturer	Bayer Pharms	Merck
Dosage forms	Topical	Injectable, Tablet
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	—
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Adrenal Insufficiency, Asthma, Berylliosis

cort-dome cortone

Rating

New

70/100

Pharmacy pays

$0.15 /g

—

Type

Active ingredient

HYDROCORTISONE

CORTISONE ACETATE

Manufacturer

Bayer Pharms

Merck

Dosage forms

Topical

Injectable, Tablet

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

—

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

Adrenal Insufficiency, Asthma, Berylliosis

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Frequently asked questions

What is the difference between Cort-Dome and Cortone?

Cort-Dome contains Hydrocortisone, while Cortone contains Cortisone Acetate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.