CORT-DOME vs CORTEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	CORT-DOME	CORTEF
Rating	New	New
Pharmacy pays	$0.15 /g	$0.15 /g
Type	RX	RX
Active ingredient	HYDROCORTISONE	HYDROCORTISONE
Manufacturer	Bayer Pharms	Pharmacia and Upjohn
Dosage forms	Topical	Tablet
Drug class	Corticosteroid	Corticosteroid
Boxed warning	None	None
Half-life	about 1.5 hours	about 1.5 hours
Treats	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis	Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

cort-dome cortef

Rating

New

Pharmacy pays

$0.15 /g

Type

Active ingredient

HYDROCORTISONE

Manufacturer

Bayer Pharms

Pharmacia and Upjohn

Dosage forms

Topical

Tablet

Drug class

Corticosteroid

Boxed warning

None

Half-life

about 1.5 hours

Treats

Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

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Frequently asked questions

Which is cheaper, Cort-Dome or Cortef?

Pharmacies pay about the same to acquire either one — roughly $0.15 per gm, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Cort-Dome and Cortef?

Both Cort-Dome and Cortef share the active ingredient Hydrocortisone.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.