CONTRAVE vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. CONTRAVE and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CONTRAVE	MYSOLINE
Rating	New	74/100
Pharmacy pays	~$2.51 /30	~$2.89 /30
Type	RX	RX
Active ingredient	BUPROPION HYDROCHLORIDE AND NALTREXONE HYDROCHLORIDE	PRIMIDONE
Manufacturer	Nalpropion	Valeant Pharm Intl
Dosage forms	Tablet, extended release	Tablet
Drug class	—	Anti-Epileptic Agent
Boxed warning	Boxed warning	None
Half-life	about 21 hours on average (±9 hours)	—
Treats	—	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

contrave mysoline

Rating

New

74/100

Pharmacy pays

~$2.51 /30

~$2.89 /30

Type

Active ingredient

BUPROPION HYDROCHLORIDE AND NALTREXONE HYDROCHLORIDE

PRIMIDONE

Manufacturer

Nalpropion

Valeant Pharm Intl

Dosage forms

Tablet, extended release

Tablet

Drug class

—

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 21 hours on average (±9 hours)

—

Treats

—

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is cheaper, Contrave or Mysoline?

Contrave costs pharmacies less to acquire — about $2.51 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Contrave and Mysoline?

Contrave contains Bupropion Hydrochloride and Naltrexone Hydrochloride, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.