CONTRAVE vs CUPRIMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. CONTRAVE and CUPRIMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CONTRAVE	CUPRIMINE
Rating	New	74/100
Pharmacy pays	~$2.51 /30	—
Type	RX	RX
Active ingredient	BUPROPION HYDROCHLORIDE AND NALTREXONE HYDROCHLORIDE	PENICILLAMINE
Manufacturer	Nalpropion	Valeant Pharm Intl
Dosage forms	Tablet, extended release	Capsule
Drug class	—	Antirheumatic Agent
Boxed warning	Boxed warning	Boxed warning
Half-life	about 21 hours on average (±9 hours)	—
Treats	—	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

contrave cuprimine

Rating

New

74/100

Pharmacy pays

~$2.51 /30

—

Type

Active ingredient

BUPROPION HYDROCHLORIDE AND NALTREXONE HYDROCHLORIDE

PENICILLAMINE

Manufacturer

Nalpropion

Valeant Pharm Intl

Dosage forms

Tablet, extended release

Capsule

Drug class

—

Antirheumatic Agent

Boxed warning

Half-life

about 21 hours on average (±9 hours)

—

Treats

—

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

What is the difference between Contrave and Cuprimine?

Contrave contains Bupropion Hydrochloride and Naltrexone Hydrochloride, while Cuprimine contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.