COMTAN vs ONGENTYS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. COMTAN and ONGENTYS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COMTAN	ONGENTYS
Rating	New	70/100
Pharmacy pays	~$10.59 /30	—
Type	RX	RX
Active ingredient	ENTACAPONE	OPICAPONE
Manufacturer	Orion Pharma	Amneal
Dosage forms	Tablet	Capsule
Drug class	Catechol-O-Methyltransferase Inhibitor	—
Boxed warning	None	None
Treats	Parkinson Disease	Parkinson Disease

comtan ongentys

Rating

New

70/100

Pharmacy pays

~$10.59 /30

—

Type

Active ingredient

ENTACAPONE

OPICAPONE

Manufacturer

Orion Pharma

Amneal

Dosage forms

Tablet

Capsule

Drug class

Catechol-O-Methyltransferase Inhibitor

—

Boxed warning

None

Treats

Parkinson Disease

Frequently asked questions

What is the difference between Comtan and Ongentys?

Comtan contains Entacapone, while Ongentys contains Opicapone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.