COMTAN vs MIRAPEX ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. COMTAN and MIRAPEX ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COMTAN	MIRAPEX ER
Rating	New	72/100
Pharmacy pays	~$10.59 /30	~$2.01 /30
Type	RX	RX
Active ingredient	ENTACAPONE	PRAMIPEXOLE DIHYDROCHLORIDE
Manufacturer	Orion Pharma	Boehringer Ingelheim
Dosage forms	Tablet	Tablet, extended release
Drug class	Catechol-O-Methyltransferase Inhibitor	Nonergot Dopamine Agonist
Boxed warning	None	None
Treats	Parkinson Disease	Depressive Disorder, Parkinson Disease

comtan mirapex er

Rating

New

72/100

Pharmacy pays

~$10.59 /30

~$2.01 /30

Type

Active ingredient

ENTACAPONE

PRAMIPEXOLE DIHYDROCHLORIDE

Manufacturer

Orion Pharma

Boehringer Ingelheim

Dosage forms

Tablet

Tablet, extended release

Drug class

Catechol-O-Methyltransferase Inhibitor

Nonergot Dopamine Agonist

Boxed warning

None

Treats

Parkinson Disease

Depressive Disorder, Parkinson Disease

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Frequently asked questions

Which is cheaper, Comtan or Mirapex ER?

Mirapex ER costs pharmacies less to acquire — about $2.01 vs $10.59 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Comtan and Mirapex ER?

Comtan contains Entacapone, while Mirapex ER contains Pramipexole Dihydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.