COMPLERA vs RETIN-A

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 11, 2026·How we rate

Possible drug interaction. COMPLERA and RETIN-A are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COMPLERA	RETIN-A
Rating	72/100	74/100
Pharmacy pays	~$435.30 /30	$1.05 /g
Type	RX	RX
Active ingredient	EMTRICITABINE AND RILPIVIRINE HYDROCHLORIDE AND TENOFOVIR DISOPROXIL FUMARATE	TRETINOIN
Manufacturer	Gilead Sciences Inc	Valeant Pharm Intl
Dosage forms	Tablet	Topical
Drug class	—	Retinoid
Boxed warning	Boxed warning	None
Treats	—	Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

complera retin-a

Rating

72/100

74/100

Pharmacy pays

~$435.30 /30

$1.05 /g

Type

Active ingredient

EMTRICITABINE AND RILPIVIRINE HYDROCHLORIDE AND TENOFOVIR DISOPROXIL FUMARATE

TRETINOIN

Manufacturer

Gilead Sciences Inc

Valeant Pharm Intl

Dosage forms

Tablet

Topical

Drug class

—

Retinoid

Boxed warning

None

Treats

—

Acne Vulgaris, Facial Dermatoses, Acute Promyelocytic Leukemia

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Frequently asked questions

Which is better-rated, Complera or Retin-A?

By our independent rating, Retin-A scores higher — 3.7 vs 3.6 out of 5 for Complera. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Complera and Retin-A?

Complera contains Emtricitabine and Rilpivirine Hydrochloride and Tenofovir Disoproxil Fumarate, while Retin-A contains Tretinoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.